Olivia Wilde, who plays Thirteen, took a break from the show to work on some movies but Shore told TV Line that he is looking forward to writing her comeback episode.
"We have something very cool in mind," he said. "We're writing an episode built largely around her return. I know [fans] are speculating about what happened to her during her absence and I don't want to rule anything out."
Some rumours have suggested that Thirteen will die from Huntington's disease when she returns but Shore insisted that he wants to keep working with Wilde.
"We'll have to continue to work around her schedule a little bit," he said. "But it would be a crying shame for us to let her get away at this point. We've been very good to her and we'd like a little bit of it back."
Wilde is expected to return to House in the spring.