The actress recently told reporters that series lead Hugh Laurie is currently the only actor contracted for another run of the Fox medical drama.
"There are still some issues to be worked out," she explained. "I believe NBC [Universal] wants Fox to take over the cost of production, and Fox doesn't want to."
She added: "Until that's resolved, they can't even begin to talk to any of us."
The current regular cast for the show includes Edelstein (Lisa Cuddy), Robert Sean Leonard (Wilson), Omar Epps (Foreman), Jesse Spencer (Chase) and Peter Jacobson (Taub).
Olivia Wilde (Thirteen) will also return to the show later this season, while Amber Tamblyn (Martha Masters) will depart in the Spring.
House airs on Mondays at 8/7c on Fox.