The actress told TV Line that her character Martha Masters will cross paths with the returning Thirteen (Olivia Wilde) shortly before leaving the show.
"We have two episodes [together, and] one where we actually work together," she explained. "It was super, super fun."
She added: "If they hadn't given us at least one scene [together], with me being the only other female team member, it would have been a missed opportunity. I think they knew better than to pass that up, so they gave us some really cool scenes together."
Tamblyn also revealed that the producers of House were originally keen to keep her on as a series regular.
"They really wanted me to stay, but there are reasons I have to leave, because of other things I'm doing," she said. "It was my 13th episode, and that's when Olivia had finished her film and was due back."
The former Joan of Arcadia star insisted that she is sad to be leaving the Fox medical drama.
"House is such a great environment to work in," she claimed. "I was the most sad to say goodbye to Hugh [Laurie], because he's the most incredible and giving actor to work with."
House continues tonight at 8/7c on Fox.