After several failed attempts to get her final lumbar puncture, Masters decides to accept House's internship, but he forges the final LP on her medical log and tells her that she can only join his team if she hands in the forged document. However, Thirteen later offers Masters the opportunity to perform the final LP on her. Meanwhile, Kendall falls into unconsciousness and suffers from poor blood flow to one of her arms. Further tests appear to reveal that her pineal gland has become calcified and the team start the patient on hormone therapy.
Masters departs House's team and starts a surgical internship. On her first day, her advice proves vital in saving a patient's life, which impresses the head surgeon. He invites Masters to scrub in on his next procedure, but she is distracted when she learns that Kendall's previous treatment failed and that she is still a patient. Masters makes an excuse and leaves the surgery to attend Kendall's operation. Impressed by her subterfuge, House welcomes her back to the team, but she insists that she is only staying for this one case.
Masters tells Kendall that her arm needs to be amputated to save her life, but the teenager is desperate to delay her treatment and sail around the world. Kendall's mother bows to her demands, as does her father, albeit reluctantly. When Masters confronts House with the issue, he tells her that she must break the rules to save Kendall's life. Masters tries one final time to convince Kendall to have the surgery, and when she refuses, Masters gives her a special "medicine".
The next day, Masters admits to House that she manipulated, lied, forged and stole to save Kendall's life, and that she now feels terrible. She tells House that she has to leave, as she cannot play by his rules. He warns Masters that "Nothing will ever be simple again" but she replies, "I'm fine with that" and proudly leaves the hospital.
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