Annable will be a series regular when the show returns for its eighth season in October, Deadline reports.
Details of Annable's character have not yet been confirmed, but she is expected to play a doctor working at the prison where House (Hugh Laurie) is being held after driving into Cuddy's home in the season seven finale.
House allegedly ends up recruiting Annable's character to join his team at Princeton-Plainsboro.
Annable's entrance follows the news that Lisa Edelstein will not be returning to the show. Recurring star Amber Tamblyn has also completed her arc on the series, while cast member Olivia Wilde is expected to take further breaks to pursue her movie career.
Annable's House contract reportedly includes space for her to continue working on Fox's show Breaking In if it is picked up. The series was cancelled in May but reports have suggested that it could yet be saved.
Annable has also appeared in Brothers & Sisters as Annie, a love interest for Justin, who was played by her real-life husband Dave Annable. She has also worked on shows including October Road and South Beach and had a role in the movie Cloverfield.
House will return with its eighth season on October 3 on Fox.
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