The Cloverfield star will appear in the medical drama's eighth season as a prison doctor who later transfers to House's team at Princeton-Plainsboro.
"She's working in prison and there's a bit of a connection," Shore told Entertainment Weekly. "[But it's] not a physical connection [because] she doesn't really know House. He's just a prisoner."
Shore added that "things [will] change" between Annable's character and House (Hugh Laurie), who will be jailed after driving his car into Cuddy (Lisa Edelstein)'s home.
"[House] changes her, and she changes him," hinted the showrunner.
He went on to say that the eighth season of House will return to "the basics" of what made the show successful, and will focus on "the fundamental questions of right and wrong".
"We're excited about it," he said. "[And Odette is] great. She's smart [and] she's funny."
House will return to Fox on October 3.
> House casts Knocked Up star Charlyne Yi
Watch the final moments of House's seventh season below: