The medical drama's eighth season will begin with House (Hugh Laurie) serving time in jail, after driving his vehicle into the home of Cuddy (Lisa Edelstein).
Shore told TV Line: "We... wanted to play with the notion of how much does he feel a sense of responsibility [over what happened]. He would never admit it but [his feelings of guilt are] there."
The showrunner added that House "has to pay a price" for his actions, but denied that the maverick doctor was attempting to kill his ex-girlfriend Cuddy.
"It was certainly an act of violence, and it was certainly an irresponsible act.," he argued. But I do feel strongly that he was not trying to kill anybody."
Shore confirmed that House will have spent "months" in jail when the new season begins.
"Season eight is going to start months after season seven ended," he said. "[But] we want to get back to the core of our show."
He continued: "Our show isn't about House in prison... so we want to get back to the core values of our show as soon as possible, but obviously with a slightly different set-up."
He went on to suggest that "the passage of time" off-screen will provide "closure" to the House / Cuddy relationship.
"We had to go down that road [of exploring their romance]," he said. "I'm proud of the way we went down that road, [even though] it was polarising to some extent."
House will return to Fox on October 3.
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Watch House's attack on Cuddy in the House seventh season finale below: