The next run of the Fox medical drama will introduce new regular characters played by Odette Annable and Charlyne Yi.
"Bringing in new blood into the hospital is always an opportunity," Shore told TV Guide. "House is at his best when he's dealing with new people and new situations and making deductions about new people and these situations."
He continued: "I certainly think the way we're starting this year is really invigorating and we're going back to our roots a little bit."
Shore insisted that bringing in new characters is "the best way to go back to basics".
"This [move] allows us to take a fresh look at who House is, to get fresh eyes on his character and how unusual he is," he said. "Through these new characters' viewpoints, we get a jaded view of House."
The showrunner also revealed that the new season of House will focus less on the central character's love life.
"I don't want [the show] to be about relationships in the sense of who's sleeping with who," he said. "At least not in the foreseeable future. It's about relationships in terms of how these people relate to each other. And the impact House's world view has on all the people around him."
House will return to Fox on October 3.
> House exec: 'Cuddy exit won't be big story'
Watch the final scene from the House seventh season finale below: