The Breaking In star will appear in the Fox medical drama's eighth season as prison medic Dr Adams.
"It's very intimidating looking at the script," Annable told IGN. "You've got to really know what you're doing. So I'm ready for it. I'm ready for the challenge, and I'm excited about it."
The actress added that she initially struggled with the medical jargon that her character is made to deliver.
"You have to say these words as if you've said them a million times before, and they're just a part of your vocabulary," she said. "But that's what preparing is for, and you can't just really wing it."
Annable previously insisted that her character is not intended as a replacement for Lisa Edelstein's Cuddy, who will not appear in the new season.
House will return to Fox on October 3.
> House exec: 'Next season could be the last'
Watch the final scene from the House seventh season finale below: