Wilde's character Dr Remy 'Thirteen' Hadley made her exit from House in Monday's episode 'Charity Case', after House fires her so she can move to Greece with her girlfriend.
The actress said she is happy with her character's story arc and doesn't expect to return again despite the show's current season being its last.
"I think the way we left it, if she came back, it would probably seem forced," Wilde told EW at the In Time premiere in Hollywood this week.
"So I don't think she should come back," Wilde explained. "I liked her exit story a lot, so I am happy with it."
House creator David Shore previously confirmed Wilde would have a 'reduced role' on the show's eighth season, but ultimately the actress only appeared in a single episode.
House continues on October 24.
> House - 'Charity Case' recap
Watch a preview of Olivia Wilde's final appearance on House below: