The series star is due to take the director's chair for episode 19 of the show's final season, TVLine reports.
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No further details about the episode have yet been revealed.
Laurie first directed an episode of House during the show's sixth season in 2010.
Executive producer Katie Jacobs said at the time that she had been asking the actor to direct an episode of the show "for years", while Laurie spoke of being "absolutely fascinated" by the process.
Laurie has also hinted that he will spend more time on writing or directing after House comes to an end.
It was recently reported that former cast members Jennifer Morrison and Lisa Edelstein will not return for the series finale.
House airs on Mondays at 8/7c on Fox. The series finale will air on May 21.
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