The actor revealed that House will continue with his "to hell with you all attitude" after discovering his friend's illness in the latest episode.
Laurie told TV Guide: "For better or for worse, they are bound together. They share a way of looking at the world, and I think they need each other.
"I think the audience will be happy, not because House has learned some life lessons - that's not what he's about.
"I think people will be happy for him. The fact that he's still got a 'mud in your eye, to hell with you all' attitude, I sort of love."
Producer David Shore recently teased that the show's final episode, entitled 'Everybody Dies', will see House "assessing his life, and his future".
House continues Mondays at 9/8c on Fox.
> 'House' final episode - First promo picture released