Hugh Laurie, Omar Epps thank 'House' fans in series wrap video - watch
The Fox show will end its eight-season run on Monday, May 21 at 9pm ET.
"My experience of House fans and the House audience is that these are people of rare intelligence and good humour and humanity," said Laurie, before adding that he admires anyone who responds to it.
"I like you. I feel as if I know you and I like you," he quipped.
Epps, meanwhile, claimed that a "thank you" is not enough for "the best fans in the world".
"To all the House fans worldwide, thank you is not enough," he shared. "Thank you for coming on this journey with us. Thank you for letting us entertain you guys, for being so crazy and involved."
Cast member Robert Sean Leonard recalled a moment when he performed on a Broadway play last year where he got the chance to meet the show's "cool" fans.
Jesse Spencer previously revealed that House will have an "appropriately satisfying ending for long-time viewers".