The actor, who plays Ben Linus in the ABC drama, told Extra that he would jump at the chance to star opposite wife Carrie Preston (Arlene Fowler) in the vampire series.
Preston previously made a cameo appearance in Lost playing Emerson's mother in a flashback scene.
"I think it would be fun if I got to play her father," he joked.
"I would go on any Alan Ball show to do just about anything. I will be the face in the window, I will be the cab driver... I don't want to be a vampire."
Preston added: "I think you should be a shape-shifter or something... Maybe [you] should not be a bad character at all... maybe you should be a good guy."
Emerson picked up the outstanding supporting actor in a drama series prize at this year's Emmy Awards.