The duo had a short relationship earlier in the series and Wesley told Zap2It that she thinks they are compatible.
"He's so hooked on Sookie!" she said. "You know, as Rutina, the actress, I would love to see them back together again, because I think they get each other. I mean, if she can just let her defences go and let her blinders go and see this man in front of her."
Wesley explained that Tara originally rejected Sam because she was scared of getting too close to him.
"I think they had something going on, I just think she wasn't quite ready for it yet," she said. "And she couldn't quite admit that she was sort of falling in love with Sam. I think whenever Tara gets close to someone, she runs away. Whenever she starts to feel something real, she starts to run away, as I know a lot of women do.
"You feel it and you're like, 'Oh, I'm going to run away' because you're afraid of being abandoned. So you self-sabotage it, and Tara's a self-sabotager. But I think, you know, I would love to see them do something together. I don't know if it's going to happen, though."
True Blood continues on Sundays at 9pm on HBO.