The actress, who plays Holly, told Movieweb that people can relate to the show despite the supernatural themes.
"I think the show does a good job in creating its own reality," she said. "It's funny. Because it's so big and over the top. When I find myself out in the world, I start to view it through those eyes. It doesn't seem so over the top anymore."
She continued: "Real life is crazier than fiction. I don't know. I go back and forth between thinking the show is over the top and not. Obviously, it does bring in all of these otherworldly elements. Most of them are analogies for the real world."
Bowles also suggested that people love what vampires represent, saying: "I just think that vampires are the ultimate symbol of the bad boy outsider. And that's an iconic image that resonates with a lot of people. Whether you feel that you are the outsider or if you are drawn to the dangerous outsider. Whatever side you fall on I feel that it resonates with so many people because it symbolises something in all of us that we can relate to."
Bowles added that it is important that True Blood still has humorous moments.
"It's not like we're going for laughs, but don't you find that some of the characters aren't too serious?" she said. "If we are really presenting reality, it can be so crazy and tragic. But below the tragedy there is a laugh to be had. It doesn't even need to be had. It just happens naturally. It can get so real, you can't help but find something to laugh about.
"Six Feet Under had that. American Beauty had that. [Executive producer] Alan Ball has a very dark sensibility, but it's a twisted, funny one that I really gravitate towards."
True Blood continues on Sundays at 9pm on HBO.