Wesley told Fancast that she thinks a relationship between Tara and Sam (Sam Trammell) "could work".
"Some of my favourite scenes [this season] have been when we've seen Tara with Sam," she explained. "Seeing Sam comfort her is nice.
"As Rutina the actor, I love to see those two together because they make sense to me. They really get each other. I just don't know if Tara will ever be stable enough to see him for who he is and see that he's a good guy."
Wesley also admitted that Tara has been unlucky in love in the past, saying: "If you think about it, there's no father figure around [for her]. I know a lot of women who grew up without fathers or a male figure in their life. It had an effect on the men that they choose in their lives.
"That's partly what I think for my backstory. Tara didn't have a male figure around to help in that area and her mother was a drunk. Her mother probably didn't have good luck with men either, so Tara's following suit."
Wesley added that she likes the fact Tara is a human character rather than a supernatural creature because she can show more emotion.
"I actually love the fact that she's human," she said. "To me that's the interesting part of the show, the human reaction to everything. Tara tells it like it is. A lot of people don't listen to her, but usually she's right. She's very observant."
True Blood continues on Sundays at 9pm on HBO.