The 35-year-old opened up about Sookie (Anna Paquin) and Alcide's recent hookup on Sunday (July 1) night's episode of the HBO series.
"Their relationship goes a lot deeper than that," Manganiello told TV Guide, insisting that Sookie will not regret her tryst with the werewolf.
"The fun thing about that scene is that it plays really real and adult," he continued. "Kids at home, that is how babies are made."
The comment appears to suggest that Sookie and Alcide's drunken night of passion could lead to a child.
Paquin is currently expecting twins with husband Stephen Moyer. There has been no word yet on whether the pregnancy will be written into the show.
True Blood was renewed for a sixth season earlier this week.