Meloni's vampire character Roman was staked by Russell (Denis O'Hare) in Sunday night's (July 15) episode of the HBO drama.
"For the time being, he's dead," the actor told TVLine. "I think that was my swan song."
He added: "We had always decided that this was the way to go."
Despite his brief five-episode stint, the former Law & Order: SVU star insisted that he had enjoyed his time on True Blood.
"I think part of the success of the show is what you are truly seeing is actors who are happy and really enjoying what they're able to do," he suggested. "I fit right in with them."
The fifth season of True Blood continues on Sundays at 9pm on HBO in the US. In the UK, the series premieres on FX.