Beaver's character Bobby Singer was killed off in the CW drama's midseason finale, after sustaining a bullet wound to the head.
"We would never let an actor as good as Jim Beaver go forever and ever," Gamble told TVLine. "We fully intend to see him again in some way.
"I can't give away everything, but I can say at the very least, we could do something like flashbacks to earlier in their lives, or bring him in in some other way."
Gamble also confirmed that Misha Collins will return as the angel Castiel, but refused to elaborate on the character's reappearance.
"He's coming back!" she said. "Soon! I can say maybe not in exactly the form you've seen him [in] before."
Ringer actor Jason Dohring will appear in the next episode of Supernatural as the god of time Chronos, while Vampire Diaries star Sara Canning has also filmed a guest role.
Supernatural continues on Fridays at 9/8c on The CW.
> Supernatural: 'Adventures in Babysitting' recap
Watch a preview for the next Supernatural below: