The first series of police drama The Chicago Code began transmission on the network in February. Creator Shawn Ryan, who had reportedly been planning a second series, confirmed the news on his Twitter account.
"Thanks for the kind words everyone," he wrote. "We tried to make the best show we could and we thank those of you who watched it... Fox suits loved the show, but have a business to run.
"Will double check, but still believe final.2 eps (sic) will air as scheduled. Think you'll like how things wrap up."
He joked that the cancellation would give him "time to guest star on the season finale of The Office with everyone else".
Ryan also expressed his sadness at the apparent cancellation of Lie to Me, offering "sympathies to all the talented people over there". He had previously served as showrunner on the crime drama.
Fox had declined to commission extra episodes of the show, which stars Tim Roth as psychologist Cal Lightman, earlier in the year.
Reports also suggest that Human Target, which is loosely based on the DC Comics title of the same name, has been cancelled after two seasons.
Showrunner Matt Miller had already revealed that he thought the show's future was uncertain.
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