The former Dawson's Creek star has entered discussions with Diaries creator Kevin Williamson, who also worked on Dawson's.
Asked if the pair are still in touch, Van Der Beek replied: "Yeah I do talk to him actually - fairly regularly."
He added that Williamson has not approached him for a part on The Vampire Diaries, but confirmed that they have been "talking about maybe going down and directing one of the episodes".
Van Der Beek currently stars in Mercy, which continues tomorrow night at 8pm on NBC.
> Click here to read our full interview with James