Speaking to Zap2It, Dobrev revealed that Elena will be furious that Stefan (Paul Wesley) brought John (David Anders) back to Mystic Falls.
"She feels like everyone around her is against her," she said. "She has one thing in mind - she wants to sacrifice herself to save her family and her friends, and they are hell-bent on stopping her. It almost feels like everyone is against her. Now her father comes home on top of everything, and he's in cahoots with everyone about it."
Dobrev continued: "He's no-one in her life as far as she's concerned. She doesn't care about him and she doesn't want to care about him. It's really almost annoying, and she's angry. She feels alone in the whole process."
Dobrev explained that Elena will end up turning to Elijah (Daniel Gillies).
"Elijah, out of everyone, is the only person who's actually forming an alliance with her, so her biggest enemy is her closest ally," she said. "The people who she's closest to, and who she's trying to save, are just holding her back."
The Vampire Diaries airs on Thursdays at 8/7c on The CW in the US. The show returns in the UK on February 1 at 9pm on ITV2.