This year, the network has pushed back its premieres to October, instead of following the traditional roll-out in mid-September.
Hart of Dixie kicks off two weeks of premieres, with its second season debuting on Tuesday, October 2 at 8pm.
Supernatural returns on Wednesday, October 3 at 9pm, while 90210 and Gossip Girl are set to debut on Monday, October 8 at 8pm and 9pm respectively.
Wednesday, October 10 will see the series premiere of Arrow, while Thursday, October 11 features the return of The Vampire Diaries, as well as the series premiere of Beauty and the Beast.
On Tuesday, October 16, the network's new medical show Emily Owens, MD will make its debut following a fresh episode of Hart of Dixie.
Finally, Friday, October 19 sees the premiere of America's Next Top Model: College Edition at 8pm and Nikita at 9pm.
Check out the full lineup below:
TUESDAY, OCTOBER 2
8-9PM: HART OF DIXIE (Season Premiere)
WEDNESDAY, OCTOBER 3
9-10PM: SUPERNATURAL (Season Premiere)
MONDAY, OCTOBER 8
8-9PM: 90210 (Season Premiere)
9-10PM: GOSSIP GIRL (Season Premiere)
WEDNESDAY, OCTOBER 10
8-9PM: ARROW (Series Premiere)
THURSDAY, OCTOBER 11
8-9PM: THE VAMPIRE DIARIES (Season Premiere)
9-10PM: BEAUTY AND THE BEAST (Series Premiere)
TUESDAY, OCTOBER 16
8-9PM: HART OF DIXIE
9-10PM: EMILY OWENS, M.D. (Series Premiere)
FRIDAY, OCTOBER 19
8-9PM: AMERICA'S NEXT TOP MODEL: COLLEGE EDITION
9-10PM: NIKITA (Season Premiere)