Williams will play Adelle, boss of the Dollhouse, which is home to a set of young men and woman whose personalities can be programmed for them to carry out missions. Fox has ordered a pilot of the show, from Buffy creator Joss Whedon.
Elsewhere, Billy Campbell (The 4400) will star in two-hour Sci Fi Channel pilot Revolution. The project is set on a human colony on another planet in the 22nd century and Campbell will play soldier-turned-farmed Tom Hart.
Molly Ringwald has agreed to star in an untitled series from Brenda Hampton (7th Heaven) for ABC Family which revolves around a teen unexpectedly realising she is pregnant.
Will Kemp has signed to a remake of former Channel 4 series Ny-Lon, while Matthew Lillard has taken a lead role in detective drama Exit 19, both pilots for CBS. Yara Martinez has joined Fox's version of Spaced; and Eion Bailey and Jay Hernandez have been hired to CBS's Can Openers.