The America's Got Talent host will sit down with Jimmy Kimmel on October 30, according to a post on The Howard Stern Show's Twitter page.
Stern will be joining Kimmel for his special week of shows filming in Brooklyn.
The controversial shock jock has appeared on Kimmel's ABC late-night series twice before, including a via-satellite chat.
It was recently reported that Stern was mulling over a retirement from radio once his current Sirius XM contract expires in 2015.
Stern joined the satellite company in 2006 after years of battling decency standards on terrestrial radio.