The season will begin on Monday, September 1 with the start of Gossip Girl season two, followed by the sixth run of One Tree Hill.
The network's hotly-anticipated Beverly Hills, 90210 spinoff gets a two-hour debut on Tuesday, September 2. On the following Tuesday, September 9, new drama Privileged, about a pair of rich twin teens, will premiere in the slot following 90210.
Drama series Smallville and Supernatural will begin new seasons on Thursday, September 18, followed on Friday, October 3 by comedies Everybody Hates Chris and The Game.
In reality TV, The CW will kick off new America's Next Top Model with a two-hour premiere on Wednesday, September 3. Stylista, a new series in which fashion fans compete for prizes and a magazine job, will begin on Wednesday, October 29.
Sunday nights will bring a batch of new series to The CW this season under a deal with production company Media Rights Capital, which is providing a weekly block of shows.
Romantic comedy Valentine, beginning on Sunday, September 21, is about a family of Greek Gods charged with spreading love. The show is from Kevin Murphy (Desperate Housewives) and stars Jaime Murray (Dexter).
Easy Money, a drama about a family of loan sharks with Laurie Metcalf (Desperate Housewives) and Jeff Hephner (The OC), will also begin on September 21, as will dangerous jobs reality show In Harm's Way.
Surviving Suburbia, a half-hour comedy about a family and their new neighbours, will bow on November 2.