The actress took on responsibility as project manager for her team Forté this week as competitors went head-to-head creating viral videos for a new indoor floor mop, with Lou Ferrigno acting as project manager for his team Unanimous.
The men's comedic video, featuring Ferrigno dressed in an apron and dancing with his mop, won and saw Unanimous taking home $50,000 (£31,587) for charity.
However, further tensions began to emerge in their team as Ferrigno and former American Idol star Clay Aiken were both seen sounding off about magician Penn Jillette.
> 'Celebrity Apprentice' teams make viral video, tension rises: trailer
Following a dramatic boardroom session, Carrere accepted responsibility for Forté's loss, saying: "Unfortunately I know as project manager, my head is on the chopping block."
She then asked Donald Trump if he would fire more than one person if she accepted responsibility. Trump responded that he would not, before firing Carrere.
Carrere said at the conclusion of the show: "I'm happy to leave now with my head held high. The game is getting to a place where people are getting ugly and cruel with each other, and I don't want to be a part of that. I just hope they can sleep at night."
Adam Carolla and Michael Andretti left the show in a double firing last week, while George Takei, Victoria Gotti and Cheryl Tiegs have also been eliminated from the competition.
The Celebrity Apprentice airs on NBC.