The CW series will begin a final ten-episode run this autumn, and Meester described the imminent ending as "bittersweet".
© The CW / Giovanni Rufino
© PA Images
"That's the perfect word for it," she told E! Online. "But at the same time, it's great to move on and do something different."
"Playing the same character for six years is great, but it's exciting to do other things, and also just sleeping and spending time with my family."
She went on to dispel rumours that there are plans for a Gossip Girl movie.
"I've never heard anything from producers or from anyone involved with Gossip Girl," she said. "I only hear about it when I'm asked about it in interviews."
Meester will next be seen opposite Hugh Laurie in upcoming indie comedy The Oranges, which opens in the US on October 5.
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The sixth season of Gossip Girl debuts on the CW on October 8. Watch a promo for the fifth season finale below:
