Entertainment Weekly reports that the Desperate Housewives star will play Ella, the mother of Lois Lane (Erica Durance).
Lois will apparently discover old videotapes of her deceased mother in the eighth episode, titled 'Abandoned'.
Hatcher previously played Lois Lane on ABC drama Lois & Clark: The New Adventures of Superman from 1993 to 1997.
Her former co-star Dean Cain has also previously appeared in Smallville, playing the sinister Dr. Curtis Knox in the seventh season episode 'Cure'.
The final season of Smallville begins this Friday at 8/7c on The CW.