The professional dancer, who has won the title three times during his tenure on the show, told People that he is taking a hiatus from the competition.
"I'm taking season 12 off," he said, explaining that he is currently preparing for a role in dance movie Cobu 3D.
Speaking of his role in the Romeo and Juliet-style film, Hough said: "People will see a much edgier side of me and these other styles of dance I'm capable of doing."
However, he added: "I will be making it back to Dancing With The Stars [for season 13] in the fall. I'm just taking a little break and taking this chance to grow and expand a little bit as an artist.
"It's like I told one of the producers on the show – I'll come back with a whole new set of skills."
Dancing With The Stars executive producer Conrad Green commented: "We wish Derek the best as he takes time off from Dancing With The Stars to pursue his film career, and look forward to having him return to the show in the fall."