The actress explained that she has chosen not to compete in the ballroom because she does not think she is a big enough star.
"They ask me every year, and I just can't do it," she told The Hollywood Reporter.
McCarthy further explained: "I tell them why [and say] 'You guys keep saying every year you're going to get A-List people and then it's the girl that was with George Clooney'... They better talk the walk or walk the talk - whatever that saying is."
The current Dancing with the Stars champion is actor JR Martinez, who triumphed over Rob Kardashian and Ricki Lake in last November's grand final.
Dancing with the Stars kicks off its 14th season on March 19 on ABC.
McCarthy recently revealed that she is in final negotiations to host her own talkshow.
> Jenny McCarthy: 'I'd date a bald guy with a big nose'